KMID : 1812020210270030354
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Journal of Neurogastroenterology and Motility 2021 Volume.27 No. 3 p.354 ~ p.362
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Normal Values of High-resolution Manometry Parameters With Provocative Maneuvers
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Su Hui
Krause Amanda J. Masihi Melina Prescott Jacqueline Decorrevont Alex Germond Emma Karasik Dave Kou Wenjun Pandolfino John E. Carlson Dustin A.
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Abstract
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Background/Aims: Incorporation of complementary and provocative test swallows to the high-resolution manometry (HRM) protocol offers potential to address limitations posed by HRM protocols that involve only a single swallow type. The aim of this study is to describe normal findings of a comprehensive HRM testing protocol performed on healthy asymptomatic volunteers.
Methods: Thirty healthy asymptomatic volunteers completed HRM with 5-mL liquid swallows in the supine position. They also completed 5-mL liquid swallows in the upright position, viscous swallows, solid test swallows, multiple rapid swallows, and a rapid drink challenge. HRM studies were analyzed via Chicago classification version 3.0.
Results: The median (5th-95th percentiles) for integrated relaxation pressure (IRP) on supine swallows was 11 (4-16) mmHg; IRP was lower than supine on upright liquid 9 (0-17) mmHg, viscous 6 (0-15) mmHg, solid 9 (1-19) mmHg, multiple rapid swallows 3 (0-12) mmHg, and rapid drink challenge 5 (?3-12) mmHg; P < 0.005. While an ¡°elevated¡± IRP value was observed on 1 to 2 test maneuvers in 8/30 (27%) subjects, all 30 subjects had an IRP value < 12 mmHg on at least one of the test maneuvers.
Conclusions: Normal values and findings from a comprehensive HRM testing protocol are reported based on evaluation of 30 healthy asymptomatic volunteers. Isolated ¡°abnormalities¡± of IRP and contractile parameters were observed in the majority (80%) of these asymptomatic subjects, while all subjects also had normal features observed. Thus, the definition of ¡°normal¡± should be recalibrated to focus on the entirety of the study and not individual metrics.
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KEYWORD
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Manometry, Peristalsis, Reference values, Volunteers
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